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Biochemistry/Molecular Biology

Facilities and Resources

State-of-the-art facilities, advanced technology and small classes at the Taylor Science Center mean that Hamilton undergraduates have the opportunity to work closely with instruments available only to graduate students at many schools. The Science Center is fully wireless and houses more than 100 teaching and research laboratories as well as offices and classrooms, student areas and a coffee shop.

Instrumentation Available to the Biochemistry Program

Chemistry Department Instruments
SPECTROMETRY
  • Bruker Avance 500MHz NMR
  • Thermo Electron Almega Raman Microscope
  • 2 Agilent 8453 UV/Vis Spectrometers
  • Jobin/Yvon Fluoromax-3 Spectrofluorometer
  • Shimadzu UV-2401PC UV-Vis
  • Perkin Elmer 3100 Atomic Absorption, Graphite Furnace
  • Mattson Galaxy 6020 FTIR
  • MIDAC M2501 FTIR Interferometer
  • Perkin Elmer Spectrum One FTIR Spectrometers (2), one with universal ATR attachment
  • Hewlett Packard 8452A Diode Array UV-Vis
  • SPEX 1403 Raman Monochromator
  • Spectrophysics Nd:YAG Laser
  • Nikon Microphot-FX fluorescence/phase contrast/ differential interference contrast microscope equipped with a Spot II digital camera

X-RAY DIFFRACTION
  • Rigaku Miniflex X-ray Powder Diffractometer

SEPARATIONS
  • Shimadzu LC-10AS High-Performance Liquid Chromatograph
  • Shimadzu QP5050 Gas Chromatograph/Mass Spectrometer
  • Hewlett Packard 5890A/5970B Gas Chromatograph/Mass Spectrometer
  • Hewlett-Packard G1602A Capillary Electrophoresis
  • B/R Teflon Spinning Band Distillation Column
  • ISCO UA-5 UV monitor/Foxy Fraction collector
  • Assorted Fraction Collectors
  • SpeedVac system
  • Assorted Student gas chromatographs

BIOCHEMISTRY
  • 2 SoLow –80° Freezers
  • Sorvall RC-5B Centrifuge
  • Walk-in Coldroom
  • Nanopure Water Purifier
  • Jasco P-1020 Polarimeter
  • Coy Anaerobic Glover Box

COMPUTATIONAL
  • Workstations
  • SGI Octane/O2 Workstations--5
  • Linux Workstations--12
  • Departmental Computer Lab--20 Apple Macintosh computers, 2 Dell PC’s
  • SGI Altix
  • 32 CPU SGI Altix 350, 32Gb Ram, 1.375 TB of scratch space
  • 16 CPU SGI Altix 350, 32Gb Ram, 1TB of scratch space
  • 16 CPU SGI Altix 350. 16Gb Ram, 0.5TB of scratch space
  • 2 CPU SGI Altix 350, 8Gb Ram, 230GB of scratch space
  • Total Altix: 66 CPU's, 88GB Ram, 3.105TB of scratch space
  • SGI Origin (irix64)
  • 32 CPU Origin 2000, 16GB Ram, 80Gb of scratch space
  • 64 CPU Origin 2400, 16GB Ram, 89Gb of scratch space
  • 4 CPU Origin 200, 1.5Gb Ram, 36Gb of scratch space
  • 4 CPU Origin 200, 1.5Gb Ram, 36Gb of scratch space
  • 4 CPU Origin 200, 1.5Gb Ram, 36Gb of scratch space
  • 4 CPU Origin 200, 1.5Gb Ram, 36Gb of scratch space
  • 4 CPU Origin 200, 1.5Gb Ram, 36Gb of scratch space
  • Total Irix64: 116 CPU's, 39.5Gb Ram, 350Gb of scratch space

MERCURY RESOURCES
  • 32 CPU SGI Origin 300, 32GB Ram, 788Gb of scratch space
  • 4 CPU SGI Origin 300, 2Gb Ram, 63Gb scratch space
  • 28 CPU (generic vendor) Beowulf cluster. Each node has 1 cpu, 512mb Ram, 120 Gb of scratch (shared across all nodes).
  • 156 (38 compute nodes (152), 1 head node (4)) CPU Beowulf cluster from Western Scientific.

Each node has 2 - Dual Core Opteron CPU's (total 4 cpus), 2Gb Ram, and share 2TB of scratch space across all 38 nodes.
Total: 220 CPU's 128Gb Ram, ~4 TB Scratch Space
*Total Cluster Resources: 402 CPU's, 255.5Gb Ram, 7.455TB of scratch space
(* excludes workstation machines)


CALORIMETRY/ELECTROCHEMISTRY
  • Microcal VP Isothermal Calorimeter
  • Perkin Elmer EEG/PAR Potentiostat
  • Parr Bomb Calorimeter

SYNTHESIS
  • Innovative Technologies Drybox
  • Five complete vacuum lines
  • Parr Hydrogenation Apparatus
  • Büchi Kugelrohr
  • Rotary Evaporators (13) 
 
Biology Department Instruments
GENOMICS
  • DNA/RNA purification equipment
  • DNA/RNA quantification equipment (GE Nanovue)
  • PCR (Applied Biosystems 2400, 9700, Veriti & BioRad MyCycler)
  • Quantitative real-time PCR (Applied Biosystems 7300)
  • Molecular cloning equipment
  • Agarose gel and southern/northern/western blot detection (BioRad ChemiDoc XRS system) 
  • DNA sequencing (LiCor 4300)
  • Luminometer with Dual Injectors (2020n) from Turner BioSystems

PROTEOMICS
  • HPLC with electrochemical, RAM and UV/Vis detection (Shimadzu)
  • Capillary Electrophoresis (HP)
  • Microplate spectrophotometers (Bio Rad 680XR & BioTec EL311)
  • Gel electrophoresis equipment (Hoefer PS250, Invitrogen XCell)
  • Vibrating microtome (Vibratome)
  • Cryostat
  • Fluorescent up-right and inverted microscopes (Olympus IX70, Nikon E600)
  • Tissue culture facility
Cupola