Pliskin earned his master's and Ph.D. in economics from the University of Michigan and joined the Hamilton College faculty in 1982. His recent research has examined the incidence of profit sharing and flexible workplace practices and their effects on firm performance. He has also written papers on prior information and biased estimation methods. Pliskin teaches courses on econometrics, international trade, microeconomic theory, and introductory macroeconomics. He has been a resident scholar at the Jerome Levy Economics Institute of Bard College.