11 to 15 out of 15
Influenza viruses spread quickly, are quite common and can have devastating consequences. Thus, drugs that help restrict the spread of influenza not only shorten the sickness, but save lives. This summer Daniel Mermelstein ’14, Carmen Montagnon ’13 and Alvin Wu ’13 are conducting research under Assistant Professor of Chemistry Adam Van Wynsberghe to examine the chemical interactions that these important drugs rely on to combat the flu.
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Assistant Professor of Chemistry Adam Van Wynsberghe,was a contributing author of a paper published in the June issue of the journal Chemical Biology and Drug Design. The paper, titled “Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target,” presents the results of research conducted in collaboration with researchers at the University of California-San Diego, the Howard Hughes Medical Institute and the University of Illinois at Urbana-Champaign.
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In 1918, the global influenza pandemic struck millions of families, killing a jaw-dropping 3 percent of the world’s population at the time. Scientists since devised a treatment to stop the flu infection from spreading within the body. With the recent emergence of a particularly virulent strain of avian influenza, H5N1, and the rise of the highly transmissible but somewhat less virulent pandemic H1N1 “swine flu” in 2009, many fear a repeat of this serious and lethal world health crisis. The common drugs used for treatment of influenza are far from perfect, and they sometimes act in unexpected ways on the molecular level. Working with Assistant Professor of Chemistry Adam Van Wynsberghe, Erica Losito ’12 and Jeremy Adelman ’13 are taking a closer look at exactly what happens when the virus and the drug interact, in two different ways.
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