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Angela Blum


Angela Blum
Angela Blum

Assistant Professor of Chemistry

Taylor Science Center 1076
315-859-4695

Angela Blum’s research at Hamilton focusues on materials approaches to controlling bacterial behavior and pathogenicity. Her work will be highly interdisciplinary, borrowing tactics from synthetic organic chemistry, chemical biology, and materials chemistry.

She holds a bachelor's degree in chemistry from Lewis & Clark College and a doctorate from the California Institute of Technology. At Caltech, she used techniques in physical organic chemistry to elucidate the molecular interactions responsible for activating essential neuroreceptors that bind important neurotransmitters, key pharmaceuticals and nicotine. As a postdoctoral scholar at the University of California, San Diego, she developed a general method to improve the efficacy of peptide-based therapeutics by packaging them as high-density brush polymers.

 

Recent Courses Taught

Organic Chemistry I
Organic Chemistry II

Distinctions

  • American Cancer Society Postdoctoral Fellowship, 2013
  • National Institute of Health Postdoctoral Fellowship (Ruth L. Kirschstein National Research Service Award); funding declined, 2012
  • National Science Foundation Graduate Research Fellowship, 2006

Patents

  • "Compositions of Cell Penetrating High Density Peptide Polymers." Blum, A. P., Kammeyer, J.K., Gianneschi, N. C. U.S. Patent Application filed on August 8, 2015.
  • "Synthesis of N-Heterocyclic Carbene-Containing Metal Complexes from 2-(Pentafluorophenyl) Imidazolidines." Blum, A. P., Ritter, T. and Grubbs, R.H., Provisional U.S. Patent Application filed on February 23, 2007.

Select Publications

  • Blum, A. P., Kammeyer, J. K., Yin, J., Crystal, D. T., Rush, A. M., Gilson, M. K., Gianneschi, N. C. "Peptides Displayed as High Density Brush Polymers Resist Proteolysis and Retain Bioactivity." J. Am. Chem. Soc. 2014, 136, 15422-15437. PMID: 25314576.
  • Rush, A. M., Nelles, D. A., Blum, A. P., Barnhill, S. A., Tatro, E.T., Yeo, G. W., Gianneschi, N. C. "Intracellular mRNA Regulation with Self-Assembled Locked Nucleic Acid Polymer Nanoparticles." J. Am. Chem. Soc. 2014, 134, 7615-7618. PMID: 24827740.
  • Kammeyer, J. K., Blum, A. P., Adamiak, L., Hahn, M. E., Gianneschi, N. C. "Polymerization of Protecting­-Group-Free Peptides via ROMP." Polym. Chem. 2013, 4, 3929-3933. PMID: 24015154.
  • Blum, A. P., Van Arnam, E. B., German, L. A., Lester H. A., Dougherty, D. A. "Binding Interactions to the Complementary Subunit of Nicotinic Receptors." J. Biol. Chem. 2013, 288, 6991-6997. PMID: 23349463.
  • Da Silva Tavares, X., Blum, A. P., Nakamura, D. T., Puskar, N. L., Shanata, J. A. P., Lester, H. A., Dougherty, D. A. "Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor." J. Am. Chem: Soc. 2012, 134, 11474-11480. PMID: 22716019.
More... Less...
  • Blum, A. P., Gleitsman, K. R., Lester, H. A., Dougherty, D. A. "Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor: Role of the Vicinal Disulfide of the α1 Subunit." J. Biol. Chem. 2011, 286, 32251-32258. PMID: 22716019.
  • Blum, A. P., Lester, H. A., Dougherty, D. A. "Nicotinic pharmacophore: The Pyridine N of Nicotine and Carbonyl of Acetylcholine Hydrogen Bond Across a Subunit Interface to a Backbone NH." Proc. Nat. Acad. Sci. 2010, 107, 13206-13211. PMID: 20616056. 
  • Eastwood, A. L.*, Blum, A. P.* Zacharias, N. M., Dougherty, D. A. "A Selenide-Based Approach to Photochemical Cleavage of Peptide and Protein Backbones at Engineered Backbone Esters."}. Org. Chem. 2009, 74, 9241-9244. PMID: 19902952.
  • Blum, A. P., Ritter, T., Grubbs, R. H. "Synthesis of N-Heterocyclic Carbene-Containing Metal Complexes from 2-(Pentafluorophenyl)imidazolidines." Organometallics 2007, 26, 2122-2124.
  • Kuo, L. K., Blum, A. P., Sabat M. "P-S Bond Scission by Bis(cyclopentadienyl)-Molybdenum(IV) Dichloride, Cp2M0Cli(aq): First Documented Example of an Organometallic Complex Hydrolyzing Thiophosphinates." lnorg. Chem. 2005, 44, 5537- 5541. PMID: 16022553. 

* denotes equal contribution

Appointed to the Faculty: 2016

Educational Background

Ph.D., California Institute of Technology
B.A., Lewis & Clark College

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